Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study

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atmire.migration.oldid1935
dc.contributor.advisorBoyd, Steven K.
dc.contributor.authorNour, Munier Anwar
dc.date.accessioned2014-02-03T19:28:55Z
dc.date.available2014-03-15T07:00:21Z
dc.date.issued2014-02-03
dc.date.submitted2014en
dc.description.abstractCaused by total or partial X-monosomy, Turner Syndrome (TS) is the most common chromosomal disorder in females. Commonly associated features include short stature, ovarian failure and osteoporosis in adult years. Childhood short-stature in TS is commonly treated with growth hormone (GH). This historic cohort-study using dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) was conducted to determine the effect of childhood GH treatment on adult bone quality in TS women. Karyotype confirmed TS women aged 16-45 years were recruited (N=28). GH-treated subjects were 7.4 cm taller than non-GH-treated (p<0.05). Groups were similar in regard to known bone health risk factors. GH-treated subjects had significantly larger bone areas (9-25%, p<0.05) by DXA and HR-pQCT. Bone densities, micro-architecture and estimated fracture thresholds were not different among treatment groups. While no micro-architectural benefits were observed with GH-treatment, the persistent macro-structural differences may provide advantages in future fracture risk.en_US
dc.identifier.citationNour, M. A. (2014). Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26456en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26456
dc.identifier.urihttp://hdl.handle.net/11023/1363
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subject.classificationTurner Syndromeen_US
dc.subject.classificationosteoporosisen_US
dc.subject.classificationHigh Resolution Peripheral Quantitative Computed Tomographyen_US
dc.subject.classificationGrowth Hormoneen_US
dc.titleImpact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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