Molecular mechanisms of muscle force regulation: a role for titin?
Date
2012-01
Journal Title
Journal ISSN
Volume Title
Publisher
Exercise Sport Science Reviews
Abstract
Muscle contraction and force regulation is thought to occur exclusively through the interaction of the contractile proteins actin and myosin and in accordance with the assumptions underlying the cross-bridge theory. Here, we demonstrate that a third protein, titin, plays a major role in muscle force regulation, particularly for eccentric contractions and at long muscle and sarcomere lengths.
Description
Keywords
sarcomeres, myofibrils, cross-bridge theory, sliding filament theory
Citation
Herzog, W., Duvall, M., & Leonard, T. R. (2012). Molecular mechanisms of muscle force regulation: a role for titin? Exercise and Sport Sciences Reviews, 40(1), 50–57.