Cellular Therapy for Saccular Intracranial Aneurysms: A Proof-of-Concept Study
Abstract
Intracranial aneurysms are pathological dilations of arteries in the brain. Rupture of an aneurysm would be catastrophic, resulting in death in half of the cases and permanent neu- rological deficits in half of the survivors. The current standard-of-care for treating aneurysms is endovascular coiling, a procedure that involves packing the aneurysm with soft platinum- made coils that cause the blood within the aneurysm to clot, consequently slowing the flow of blood into the aneurysm. This is followed by a healing response that remodels the clot into fibrous tissue and regenerates a neointima layer that covers the neck of the aneurysm and isolates it from the parent vessel. Lack of proper healing in about one-fifth of the patients results in recurrence of the aneurysm. Building on a growing body of literature, this project evaluated the potential therapeutic effects of mesenchymal stem/stromal cells (MSCs) on the healing of coiled aneurysms in a rabbit model.
Description
Keywords
Medicine and Surgery, Engineering--Biomedical
Citation
Adibi, M. A. (2015). Cellular Therapy for Saccular Intracranial Aneurysms: A Proof-of-Concept Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25238