Cellular Therapy for Saccular Intracranial Aneurysms: A Proof-of-Concept Study

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atmire.migration.oldid3631
dc.contributor.advisorSen, Arindom
dc.contributor.advisorMitha, Alim
dc.contributor.authorAdibi, Mohammad Amin
dc.date.accessioned2015-09-23T20:11:04Z
dc.date.embargolift2017-09-22T20:11:04Z
dc.date.issued2015-09-23
dc.date.submitted2015en
dc.description.abstractIntracranial aneurysms are pathological dilations of arteries in the brain. Rupture of an aneurysm would be catastrophic, resulting in death in half of the cases and permanent neu- rological deficits in half of the survivors. The current standard-of-care for treating aneurysms is endovascular coiling, a procedure that involves packing the aneurysm with soft platinum- made coils that cause the blood within the aneurysm to clot, consequently slowing the flow of blood into the aneurysm. This is followed by a healing response that remodels the clot into fibrous tissue and regenerates a neointima layer that covers the neck of the aneurysm and isolates it from the parent vessel. Lack of proper healing in about one-fifth of the patients results in recurrence of the aneurysm. Building on a growing body of literature, this project evaluated the potential therapeutic effects of mesenchymal stem/stromal cells (MSCs) on the healing of coiled aneurysms in a rabbit model.en_US
dc.description.embargoterms2 yearsen_US
dc.identifier.citationAdibi, M. A. (2015). Cellular Therapy for Saccular Intracranial Aneurysms: A Proof-of-Concept Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25238en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25238
dc.identifier.urihttp://hdl.handle.net/11023/2482
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subjectEngineering--Biomedical
dc.subject.classificationintracranial aneurysmsen_US
dc.subject.classificationCell Therapyen_US
dc.subject.classificationmesenchymal stem/stromal cellsen_US
dc.subject.classificationaneurysm recurrenceen_US
dc.subject.classificationendovascular coilingen_US
dc.subject.classificationStem Cellsen_US
dc.titleCellular Therapy for Saccular Intracranial Aneurysms: A Proof-of-Concept Study
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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